From La Guardia to the Metropoloco Zone:

From La Guardia you can take one of three different buses to the subway. Take the Q33 bus to the Subway Number 7 (last stop), then take the 7 to Manhattan.

If you're heading for the metropoloco office
take the 7 train to Central Station, change to the 6 train, ride it to Bleecker Street. Get off, get out, walk/ride east . Bleecker Street turns into 2nd Street

If you're heading for the World Welcome Party on Wednesday the 23rd, noon till midnight at 353 Broadway:
take the 7 train toCentral Station, change to the 6 train, go DOWNTOWN to Canal Street, walk/ride one block east to Broadway, make a right and walk/ride down till you hit the Paaaartey.

The website for further info:

http://www.panynj.gov/aviation/lgtsfram.htm